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A major determinant of serum aminoglycoside concentration is the volume of distribution (Vd), which has been reported to be larger than normal in patients with hematologic malignancies. But, the cause of the large Vd seen in these patients is not known. In this study we would like to confirm that the Vds of korean patients with hematologic malignancies are larger than population value, and reveal the effect of hydration and malignancy itself on Vds. We conducted a retrospective study with 15∼70 year old patients receiving TDM, who hospitalized at our hospital between 1994 and 1997. Forty patients with a malignancy were hydrated(1st group). In the patients without a malignancy, 34 patients were hydrated(2nd group) and 32 patients were not hydrated(3rd group). Pharmacokinetic parameters were determined by the method of Sawchuk et al. Student t-test was used to determined statistical differences between group means. Vd of aminoglycosides of 1st group was significantly greater than that of 3rd group (p<0.05). Vd of aminoglycosides of 2nd group was greater than that of 3rd group(p<0.05). However, there is no significant differences in Vd of aminoglycosides between group 1 and group 2. We conclude the korean patients with hematologic malignancy also have the increased Vd, which is affected by hydration associated with the chemotherapy.
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